Research &
Surveillance

To prevent infections, our multidisciplinary team monitors where diseases are spreading, and investigate to understand how and why. Our work covers a range of topics, all aiming to promote and implement better healthcare in Bangladesh and worldwide.

Infectious Disease

Our disease detectives are hard at work every day to understand microorganisms which cause deadly diseases.

Genomics

We learn more about microorganisms by looking at the molecular level to understand how they work.

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Antimicrobial Resistance (AMR)

Increasing resistance of bacteria to antibiotics is one of the world’s biggest concerns, we monitor AMR and also seek novel antimicrobials.

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Demographic Surveillance

Not all children who fall sick visit the hospital, so we look to the community as well to truly understand child health.

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Ongoing Projects

2020-2022
St George’s, University of London
Samir Saha (Co-PI)

NeoCHG

Efficacy and safety of chlorhexidine cleansing in reducing bacterial skin colonization of hospitalized low birthweight neonates: A pilot trial (NeoCHG)

2020-2021
ImmuneMed Inc (Right Fund)
Samir Saha (Co-PI)

Rapid Diagnostic Test

Develop Immunochromatographic based rapid diagnostic test for the both Typhoid fever and Paratyphoid fever

2020-2021
George Mason University (BMGF Fund)
Samir Saha (Co-PI)

Campylobacter Emergence

Campylobacter emergence and transmission in rural Bangladesh

2018-2022
The Hospital for Sick Children (BMGF Grant)
The Hospital for Sick Children (BMGF Grant)

“Synbiotics for the Early Prevention of Severe Infections in Infants (SEPSIS) trial”

CHRF is the key partner on laboratory-related activities that pertain to the SEPSIS Study primary endpoint, severe infection. Specifically, CHRF is engaged in blood specimen collection, laboratory analyses, the interpretation and reporting of lab-based findings, collaboration with the Lead Site in the dissemination of Study findings

2017-2021
International Vaccine Institute (IVI)
Samir Saha (PI)

TunDRA

Real-time Tracking of Neglected Bacterial Diseases and Resistance Patterns in Asia (TunDRA)

2015-2021
Sabin Vaccine Institute (BMGF Grant)
Samir Saha (PI)

Surveillance for Enteric-Fever in Asia Project (SEAP)

Data management of Multi of Surveillance for Enteric-­‐Fever in Asia Project (SEAP), Bangladesh, Nepal and Pakistan. This project will support in managing the data generated by SEAP projects in Bangladesh, Nepal and Pakistan.

2016-2022
Sabin Vaccine Institute (BMGF Grant)
Samir Saha (PI, Bangladesh)

Surveillance for Enteric-Fever in Asia Project (SEAP)

This prospective study will generate comprehensive data on burden of typhoid and para-­‐typhoid fever in Bangladesh, using the established network of sentinel and population-based sites. The project also has a follow-­‐up component to measure the deaths and disabilities from this disease. Multi country project, overall PI: Denise Garratt

2018-2021
Edinburgh University (NIHR Fund)
Samir Saha (PI, Bangladesh)

RESPIRE

To reduce the impact of and the number of deaths caused by respiratory diseases in South Asia (RESPIRE) Multi country project, overall PI: Prof. Aziz Sheikh (PI)

2018-2021
Bill & Melinda Gates Foundation Grant
Samir Saha (PI)

Impact of pneumonia and Respiratory Syncytial Virus (RSV)-infections on the Health System of Bangladesh

To generate evidence about both direct and indirect effect of high burden diseases like RSV-infections and guide informed policy decisions based on impact of diseases on the overall health system. Generated data can also be used for comprehensive analysis of impact of PCV10 on all pneumonia cases, whether admitted in the hospital, or refused hospitalization.

2020-2022
Bill and Melinda Gates Foundation
Samir Saha (PI)

Enhancing capacity of COVID-19 diagnostics in Bangladesh

To enhance COVID diagnostic in Bangladesh for pediatric and adult population, generate strong epidemiological data, determine rates of infections in health care providers, establish a genome sequencing platform for SARS-CoV-2, and establish a cohort of COVID-19 cases for long-term longitudinal follow-up.

2020-2022
Bill and Melinda Gates Foundation
Senjuti Saha (PI), Samir Saha (Co-PI)

Child Health Research Foundation Infectious Disease Observatory

To set up a mid-throughout sequencing facility (NextSeq2000) in Bangladesh for whole genome sequencing of bacterial and viral pathogens, and metagenomic sequencing of biological samples.

Completed Projects

2018-2020
Bill and Melinda Gates Foundation
Samir Saha (PI)

Impact of rotaviral Diarrhea on the health system of Bangladesh

Burden of rotaviral diarrhea in hospitalized children ≤5 years of age and incidence of rotaviral diarrhea in urban Bangladesh, diagnosis and outcome of cases refused hospitalization due to unavailability of beds

2018-2019
Bill & Melinda Gates Foundation Grant
Samir Saha (PI)

Elucidating the Causative Agents of Meningitis with Unknown Etiology using Metagenomics.

This study will work will explore the with the aetiology among the cerebrospinal fluids where no aetiology could not be detected using the available technologies (culture, serology, PCR , rtPCR).

2016-2019
Pfizer
Samir Saha (PI)

Impact of PCV on Otitis media in Bangladesh

The study is enrolling otitis media cases to elucidate the effectiveness and impact of PCV-­‐10 using the before (pre-­‐ vaccine) after (post-­‐vaccine) design. This outpatient based project will give additional attention on the impact of PCV-­‐10 on 19A and NTHi

2014-2019
GlaxoSmithKline
Samir Saha (PI)

Impact of PCV-­10 on IPD in Rural Bangladesh (Mirzapur)

To see the impact of PCV-­‐10 on meningitis, pneumonia and sepsis by using “before-­‐after” and case-­‐control study using “indirect cohort”. This study will be done in a rural population-­‐based site (Mirzapur), using the baseline data of 2005 to 2008.

2016-2019
Bill & Melinda Gates Foundation Grant
Samir Saha (PI, Bangladesh)

Microbiology & QA

Microbiology & QA support for NP carriage studies in India at KEM Hospital, Pune and KGMU, Lucknow.

2014-2018
Bill & Melinda Gates Foundation
Samir Saha (PI)

Evaluation of 10-­‐Valent Pneumococcal Conjugate Vaccine (PCV-­‐10) Impact on Invasive Pneumococcal Diseases in Bangladesh (Sentinel Sites)

To see the impact of PCV-­‐10 on meningitis, pneumonia and sepsis by using “before-­‐after” and case-­‐control study using “indirect cohort”. This study will be done in a network of 4 sentinel sites, using the baseline data of 2007 to 2014.

2016-2018
Sanofi Pasteur
Samir Saha (LPI)

Estimate prevalence of pneumococcal carriage and serotype distribution among newborn and children

The study will generate comprehensive carriage data among newborns and children through longitudinal cohort analysis.

2013-2018
St George’s, University of London
Samir Saha (Co-PI)

Pneumococcal Vaccine Impact Assessment in Bangladesh (Sylhet)

Aimed to see the impact of PCV-­‐10 on IPD cases in a rural population-­‐based site, Sylhet

2016-2018
Save the Children (WHO)
Nawshad Uddin Ahmed (PI), Samir Saha (Co-PI)

Enhanced Management of Pneumonia in Community

This study aims to rigorously assess the benefits of an enhanced approach to community case management for pneumonia, contributing to the evidence base for revision of WHO/UNICEF integrated community case management (iCCM) tool and its harmonization with the integrated management of childhood illness (IMCI) tool.

2009-2018
Bill & Melinda Gates Foundation (BMGF Grant)
Samir Saha (PI)

Aetiology of Neonatal Infections in South Asia (ANISA)

This study aimed to find etiology of neonatal infections at 6 population-­‐based sites in Bangladesh, India and Pakistan (Total Population 2,000,000; Eligible women 400,000 and 68,000 newborns). Blood and respiratory specimens were collected from possible serious bacterial infection cases and tested for multiple bacterial and viral etiologies.

2015-2018
Cardiff University (BMGF Grant)
Samir Saha (PI, Bangladesh)

Burden of Antibiotic Resistance in Neonates from Developing Societies (BARNARDS)

Aimed to collect paired organisms from blood of babies with sepsis and rectal swabs of mothers. These paired strains will be analyzed for non-susceptibility to antibiotics. These isolates will also be subjected to whole genome sequencing to understand the mechanism of resistance and the genetic relationship between the paired isolates. Multi country project, overall PI: Timothy Walsh

2015-2017
Bill & Melinda Gates Foundation Grant
Samir Saha (PI, Bangladesh)

Group B Streptococcus Colonization

Group B Streptococcus colonization in mother-­‐newborn dyads and association with anti-­‐capsular serotype-­‐specific antibodies in low and middle income South Asian and African countries This study aims to find GBS carriage among pregnant women, and transmission from mothers to babies. Multi country project, overall PI: Shabir Madhi

2014-2016
Institute for Health Metrics and Evaluation (GAVI)
Samir Saha (PI)

Evaluation of 10-­‐Valent Pneumococcal Conjugate Vaccine (PCV-­‐10) Impact on Carriage In Bangladeshi Children

This study will be done in a rural population (Mirzapur) of Bangladesh. Impact of PCV will be measured in different age groups to understand the direct and indirect effects.

2012-2016
University of Washington (BMGF Grant)
Samir Saha (PI, Bangladesh)

Vaccination and the Paediatric Microbiome

The study has been designed to analyze the microbiome of respiratory specimens collected from <2 population and understand the impact of PCV introduction. Multi country project, overall PI: George Weinstock

2012-2015
Fondation Mérieux, France
Samir Saha (PI, Bangladesh)

Typhoid Diagnostics for Measuring Disease Burden

This project aimed to validate a Real-­‐Time PCR assay for the detection of S. Typhi, S. paratyphi A and S. spp, developed by Fondation Mérieux, in collaboration with Institut Pasteur, Child Health Research Foundation of Bangladesh and Fast Track Diagnostics. Multi country project, overall PI: Hubert Endtz

2011-2015
Johns Hopkins University (NIH)
Anne CC Lee (PI), Samir Saha (Co-PI)

Maternal Genitourinary Tract Infection and Adverse Prenatal Outcomes

Aimed to elucidate the etiology of genitourinary infections in women of rural Bangladesh.

2008-2012
Johns Hopkins University (USAID)
Abdullah Baqui (PI), Samir Saha (Co-PI)

Safety and Efficacy of Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh.

Three simplified antibiotic regimes were tested for the treatment of neonatal sepsis, without danger signs. The regimes were compared with the standard group, 14 injections of penicillin and gentamicin in 7 days. Baqui et al 2015, Lancet Global Health.