To prevent infections, our multidisciplinary team monitors where diseases are spreading, and investigate to understand how and why. Our work covers a range of topics, all aiming to promote and implement better healthcare in Bangladesh and worldwide.
Our disease detectives are hard at work every day to understand microorganisms which cause deadly diseases.
The project aims to explore and understand the individualized and heterogeneous immune responses to vaccines by employing advanced techniques in single-cell sequencing.
The project's purpose is to use AI-based tools to teach low- and middle-income scientists to perform modeling and prediction studies in public health, which are dominated by researchers...
CHRF was a part of the RESPIRE project at the University of Edinburgh. The purpose of the project was to build research capacity in LMICs and ensure research is driven by the needs.
This is a data management project on Multi-site Surveillance for Enteric-Fever in Bangladesh, Nepal, and Pakistan. It will support in managing the data generated by the SEAP projects in...
This prospective study will generate comprehensive data on burden of typhoid and para-‐typhoid fever in Bangladesh, using the established network of sentinel and population-based sites....
Using bacteriophages to study the spread of drug-resistant Salmonella Typhi across regions of Bangladesh
A Mobile Autism Risk Initiative (AMARI) to Detect Autism Spectrum Disorder in Bangladesh Children under the Age of 4
Developing skills in Next Generation Sequencing techniques for young students, professionals, and scientists in Bangladesh
In this project, we will be mainly using tools from Genotyping-by-sequencing to perform genomic surveillance of different infectious diseases existing in low and middle-income countries...
A Global Pediatric Cell Atlas of Nasal and Oral Mucosa
Global Pneumococcal Sequence Surveillance 2.0
Building Capacity for Genomic Surveillance of SARS-CoV-2 and other pathogens in resource-constrained settings
RSV infections in Bangladesh (RIB)
The project focused on determining gestational age and preterm birth rates using metabolic profiles of neonates, particularly in low-resource settings.
This is a pilot study to work out the best way to apply an antiseptic called chlorhexidine to the skin of low birth-weight newborn babies who are admitted to the Dhaka Shishu hospital.
In this project, we used techniques and tools from metagenomics to identify the microbes that affect the survival of typhi.
NIHR Global Health Research Unit on Respiratory Health
Three simplified antibiotic regimes were tested for the treatment of neonatal sepsis, without danger signs. The regimes were compared with the standard group, 14 injections of penicillin and gentamicin in 7 days. Baqui et al 2015, Lancet Global Health.
Aimed to elucidate the etiology of genitourinary infections in women of rural Bangladesh.
This project aimed to validate a Real-‐Time PCR assay for the detection of S. Typhi, S. paratyphi A and S. spp, developed by Fondation Mérieux, in collaboration with Institut Pasteur, Child Health Research Foundation of Bangladesh and Fast Track Diagnostics. Multi country project, overall PI: Hubert Endtz
The study has been designed to analyze the microbiome of respiratory specimens collected from <2 population and understand the impact of PCV introduction. Multi country project, overall PI: George Weinstock
This study was done in the rural population of Mirzapur in Bangladesh. The impact of PCV was measured in different age groups to understand the direct and indirect effects.
Group B Streptococcus colonization in mother-newborn dyads and association with anti-capsular serotype-specific antibodies in low and middle-income countries in South Asia and Africa. This study aimed to find GBS carriage among pregnant women, and transmission from mothers to babies. It was a multi-country project.
Aimed to collect paired organisms from the blood of babies with sepsis and rectal swabs of mothers. These paired strains were analyzed for non-susceptibility to antibiotics. These isolates were subjected to whole genome sequencing to understand the mechanism of resistance and the genetic relationship between the paired isolates. It was a multi-country project.
This study aimed to find etiology of neonatal infections at 6 population-‐based sites in Bangladesh, India and Pakistan (Total Population 2,000,000; Eligible women 400,000 and 68,000 newborns). Blood and respiratory specimens were collected from possible serious bacterial infection cases and tested for multiple bacterial and viral etiologies.
This study aimed to rigorously assess the benefits of an enhanced approach to community case management for pneumonia. This contributed to the evidence base for the revision of the WHO/UNICEF integrated community case management (iCCM) tool and its harmonization with the integrated management of childhood illness (IMCI) tool.
Aimed to see the impact of PCV-10 vaccine on IPD (In-patient Department) cases in a rural population-based site in Sylhet
The study generated comprehensive carriage data among newborns and children through longitudinal cohort analysis.
To see the impact of PCV-10 on meningitis, pneumonia, and sepsis by using “before-after” and case-‐control studies using “indirect cohort”. This study will be done in a network of 4 sentinel sites, using the baseline data from 2007 to 2014.
This project was to support Microbiology & Quality assurance (QA) of Nasopharyngeal Carriage studies in India at the KEM Hospital in Pune and King George's Medical University in Lucknow.
The purpose of the project was to see the impact of PCV-10 on meningitis, pneumonia, and sepsis by using “before-after” and case-control studies using an “indirect cohort”. This study was conducted in a rural population-based site in Mirzapur, using the baseline data from 2005 to 2008.
The study enrolled otitis media cases to elucidate the effectiveness and impact of PCV-10 using the before (pre-vaccine) and after (post-vaccine) design. This outpatient-based project gave additional attention to the impact of PCV-10 on Serotype (the most common serotype causing invasive pneumococcal infections in children) and NTHi (Nontypeable Haemophilus influenza).
This study worked to explore the aetiology among the cerebrospinal fluids where no aetiology could not be detected using the available technologies like culture, serology, PCR, or rtPCR.
This study examined the burden of rotaviral diarrhea in hospitalized children of ≤5 years of age, as well as the incidence of rotaviral diarrhea in urban Bangladesh. It helped to improve the outcome of cases that were refused hospitalization due to the unavailability of beds.
To set up a mid-throughout sequencing facility (NextSeq2000) in Bangladesh for whole genome sequencing of bacterial and viral pathogens, and metagenomic sequencing of biological samples.
To enhance COVID diagnostic in Bangladesh for pediatric and adult population, generate strong epidemiological data, determine rates of infections in health care providers, establish a genome sequencing platform for SARS-CoV-2, and establish a cohort of COVID-19 cases for long-term longitudinal follow-up.
This project generated evidence about both the direct and indirect effects of high-burden diseases like RSV infections and guided informed policy decisions based on the impact of diseases on the overall health system. Generated data can also be used for comprehensive analysis of the impact of PCV10 on all pneumonia cases, whether admitted to the hospital or refused hospitalization.
To reduce the impact of and the number of deaths caused by respiratory diseases in South Asia (RESPIRE) Multi country project, overall PI: Prof. Aziz Sheikh (PI)
Real-time Tracking of Neglected Bacterial Diseases and Resistance Patterns in Asia (TunDRA)
CHRF was the key partner in laboratory-related activities that pertained to the SEPSIS Study's primary endpoint. Specifically, CHRF was engaged in blood specimen collection, laboratory analyses, data interpretation, reporting of lab-based findings, and collaboration with the main site for the dissemination of study findings.
Through this project, we studied the emergence of Campylobacter bacteria in rural regions of Bangladesh and how they are transmitted.
Develop Immunochromatographic based rapid diagnostic test for the both Typhoid fever and Paratyphoid fever
Efficacy and safety of chlorhexidine cleansing in reducing bacterial skin colonization of hospitalized low birthweight neonates: A pilot trial (NeoCHG)
