CHRF has been conducting several clinical trials on treatment as early identification and prompt antibiotic therapy has been crucial in reducing the mortality and morbidity from infections. However, recently the therapy has been complicated by the emergence of high rates of resistant organisms. Such resistance is often generated by improper therapy, misuse of antibiotics and overly long durations of treatment. Rational use of antibiotics can minimize this critical situation.
Category: Clinical Trials
Safety and Efficacy of Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh (SAT)
Funded by USAID | Feb 2008 to Sep 2013 What? This was a three-cell, randomized, open-label, non-inferiority trial to establish that simplified, home-based antibiotic regimens, for families that refuse hospitalization, were not inferior compared to the standard course of parenteral …
Comparison of 5 vs. 10 days of Ceftriaxone therapy for bacterial meningitis in children (CSF-5)
Funded by WHO & JHU | Mar 2002- Feb 2004 What? A multi-country, double-blind, placebo-controlled, radomised study to determine whether equivalence between between 10 days versus 5 days of ceftriaxone therapy for treatment of acute bacterial meningitis in children aged …
Multicentre Amoxicillin Severe Pneumonia Study (MASS)
Funded by WHO | Jan 2006 – Dec 2006 What? MASS was a multi-country study that conducted community-based trials to demonstrate the safety and efficacy of a home-based oral amoxicillin treatment. Severe pneumonia patients were treated with oral amoxicillin and …
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