Clinical Trials

A clinical trial is a prospective research study on human subjects that is designed to answer particular questions regarding biomedical or behavioral interventions generating safety and efficacy data. This study is steered only after satisfactory evidence has been gathered that fulfills health authority/ethics committee endorsement in the country where approval of the therapy is required. The native ethics committee has the preference on how it will be supervised, this body is called the Institutional Review Board (IRB), and most of them are located at the local investigator’s hospital or institution. To be ethical, researchers must obtain the full and informed consent of participating human subjects. If the patient is unable to consent for him/herself, researchers can seek consent from the patient’s legally authorized representative. CHRF has been conducting several clinical trials on treatment as early identification and prompt antibiotic therapy has been crucial in reducing the mortality and morbidity from infections. However, recently the therapy has been complicated by the emergence of high rates of resistant organisms. Such resistance is often generated by improper therapy, misuse of antibiotics and overly long durations of treatment. This scenario is common in Bangladesh. Rational use of antibiotic can minimize this critical situation.

Multicentre Amoxicillin Severe Pneumonia Study (MASS)

Multicentre Amoxicillin Severe Pneumonia Study (MASS)
October 2, 2016 No Comments »

Funded by WHO  | Jan 2006 – Dec 2006 What? MASS was a multi-country study that conducted community-based trials to demonstrate the safety and efficacy of a home-based oral amoxicillin treatment. Severe pneumonia patients were treated with ... Read More »

Comparison of 5 vs. 10 days of Ceftriaxone therapy for bacterial meningitis in children (CSF-5)

October 2, 2016 No Comments »

Funded by WHO & JHU | Mar 2002- Feb 2004 What? A multi-country, double-blind, placebo-controlled, radomised study to determine whether equivalence between between 10 days versus 5 days of ceftriaxone therapy for treatment of acute bacterial meningitis ... Read More »

Safety and Efficacy of Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh (SAT)

October 2, 2016 No Comments »

Funded by USAID  |  Feb 2008 to Sep 2013 What? This was a three-cell, randomized, open-label, non-inferiority trial to establish that simplified, home-based antibiotic regimens, for families that refuse hospitalization, were not inferior compared to the standard ... Read More »